Protein name:
NADH-cytochrome b5 reductase 3 (B5R;Cytochrome b5 reductase) ;
Alternative:
Diaphorase-1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2.
Function:
Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Subcellular Location:
Isoform 2
Cytoplasm
Produces the soluble form found in erythrocytes.
Protein Attributes:
50:
MGAQLSTLGH | MVLFPVWFLY | SLLMKLFQRS | TPAITLESPD | IKYPLRLIDR |
100:
EIISHDTRRF | RFALPSPQHI | LGLPVGQHIY | LSARIDGNLV | VRPYTPISSD |
150:
DDKGFVDLVI | KVYFKDTHPK | FPAGGKMSQY | LESMQIGDTI | EFRGPSGLLV |
200:
YQGKGKFAIR | PDKKSNPIIR | TVKSVGMIAG | GTGITPMLQV | IRAIMKDPDD |
250:
HTVCHLLFAN | QTEKDILLRP | ELEELRNKHS | ARFKLWYTLD | RAPEAWDYGQ |
300:
GFVNEEMIRD | HLPPPEEEPL | VLMCGPPPMI | QYACLPNLDH | VGHPTERCFV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Human
Pig
Dog
Polyclonal Antibody for Human B5R
Polyclonal Antibody for Human B5R
Polyclonal Antibody for Human B5R
Polyclonal Antibody for Human B5R
Polyclonal Antibody for Human B5R
Polyclonal Antibody for Human B5R
Monoclonal Antibody for Human B5R
Monoclonal Antibody for Human B5R
Monoclonal Antibody for Human B5R
Monoclonal Antibody for Human B5R
Monoclonal Antibody for Human B5R
Monoclonal Antibody for Human B5R
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Simon M.I.
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Fransson I.
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Wright H.
more...
Nature402:489-495(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 8-301 (ISOFORM 1);VARIANT PRO-66
tissue :
Liver .
12.
"Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: correlative studies on cell lines and biopsy tissues."
Diss J.K.J.
,
Fraser S.P.
,
Coombes R.C.
,
Djamgoz M.B.A.
Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 101-250 (ISOFORM 1)
13.
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Cited for : PROTEIN SEQUENCE OF 2-25;MYRISTOYLATION AT GLY-2
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-301
tissue :
Erythrocyte .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-301
tissue :
Erythrocyte .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE PROMOTER USAGE
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF CYSTEINE RESIDUES
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-43;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-42;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 31-301
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT METHB-CYB5R3 PRO-128
23.
"Exonic point mutations in NADH-cytochrome B5 reductase genes of homozygotes for hereditary methemoglobinemia, types I and III: putative mechanisms of tissue-dependent enzyme deficiency."
Katsube T.
,
Sakamoto N.
,
Kobayashi Y.
,
Seki R.
,
Hirano M.
,
Tanishima K.
,
Tomoda A.
,
Takazakura E.
,
Yubisui T.
,
Takeshita M.
,
Sakaki Y.
,
Fukumaki Y.
Am. J. Hum. Genet.48:799-808(1991)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS METHB-CYB5R3 GLN-58 AND PRO-149
24.
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Cited for : VARIANT METHB-CYB5R3 MET-106
25.
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Cited for : VARIANT METHB-CYB5R3 PHE-299 DEL
26.
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Cited for : VARIANTS METHB-CYB5R3 ARG-204 AND MET-273 DEL
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SER-117
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT METHB-CYB5R3 PRO-73
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-83 AND 171-187;VARIANT METHB-CYB5R3 VAL-179
30.
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Cited for : VARIANT METHB-CYB5R3 TYR-204
31.
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Cited for : VARIANT METHB-CYB5R3 GLN-58
32.
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Cited for : VARIANTS METHB-CYB5R3 GLU-256 DEL AND ASP-292
33.
"Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase."
Percy M.J.
,
Crowley L.J.
,
Davis C.A.
,
McMullin M.F.
,
Savage G.
,
Hughes J.
,
McMahon C.
,
Quinn R.J.M.
,
Smith O.
,
Barber M.J.
,
Lappin T.R.J.
Br. J. Haematol.129:847-853(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF VARIANTS METHB-CYB5R3 GLU-256 DEL AND ASP-292